Chloroacetyl chloride → HCID 13120264, compound

HRID 1589272Notes

Reaction equation

HRID 1589272 reaction equation
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH3:6][C:7]([CH3:12])([CH3:11])[CH:8]([OH:10])[CH3:9].C(N(CC)CC)C>>[Cl:1][CH2:2][C:3]([O:10][CH:8]([C:7]([CH3:12])([CH3:11])[CH3:6])[CH3:9])=[O:4]

Participants

4

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 100453,3-Dimethyl-2-butanol

Product 1

HCID 13120264HCID 13120264, compound

Procedure

47.5 g (0.42 mole) of chloracetyl chloride was slowly added to a mixture of 40.9 g (0.4 mole) of 3,3-dimethyl 2-butanol and 58 ml (0.42 mole) of triethylamine. The reaction mixture kept at 10° C. during the running in of the acid chloride, was brought to ordinary temperature and stirred for about 4 hours. After filtration and washing with ether of triethylamine hydrochloride, the solution was washed with water then dried over sodium sulfate. After evaporation of the solvent and distillation of the vacuum, 64 g namely 89% was obtained of a pure liquid of b.p.t =79°/81° C. under 20 mm Hg.

Workup

  1. customkept at 10° C.
  2. filtrationAfter filtration
  3. washwashing with ether of triethylamine hydrochloride
  4. washthe solution was washed with water
  5. dry with materialthen dried over sodium sulfate
  6. customAfter evaporation of the solvent and distillation of the vacuum, 64 g namely 89%
  7. customwas obtained of a pure liquid of b.p.t =79°/81° C. under 20 mm Hg

Sources & evidence

ORD record
ord-acb6c5abfa874bf5992df3a4b373399d
Source dataset
uspto-grants-1986_02
Patent number
US04568754

Reaction notes

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