Sodium → HCID 13577522, compound

HRID 1589329Notes

Reaction equation

HRID 1589329 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]([S:11][CH2:12][CH2:13]Cl)=[N:9][OH:10])[CH:5]=[CH:6][CH:7]=1.[Na]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[S:11][CH2:12][CH2:13][O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 5360545SodiumHCID 86740658HCID 86740658, compound

Product 1

HCID 13577522HCID 13577522, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Cyclisation of 2-chloroethyl 3-fluoro-N-hydroxybenzenecarboximidothioate was accomplished as described in Example 2 using sodium (4.6 g) in ethanol (300 ml) to give 3-(3-fluorophenyl)-5,6-dihydro-1,4,2-oxathiazine, mp 47°-9° C. (Found: C,54.66; H,4.13; N,7.07. C9H8FNOS requires C,54.81; H,4.09; N,7.10).

Sources & evidence

ORD record
ord-581bec2d529d4cbabd769a6c9bca41a3
Source dataset
uspto-grants-1986_02
Patent number
US04569690

Reaction notes

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