Thionyl Chloride → HCID 13561107, compound

HRID 1589337Notes

Reaction equation

HRID 1589337 reaction equation
O[CH2:2][NH:3][C:4](=[O:9])[C:5]([F:8])([F:7])[F:6].S(Cl)([Cl:12])=O>ClCCl>[Cl:12][CH2:2][NH:3][C:4](=[O:9])[C:5]([F:8])([F:7])[F:6]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 30849312,2,2-Trifluoro-N-(hydroxymethyl)acetamide

Product 1

HCID 13561107HCID 13561107, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

51.7 grams (g) (0.36 mole) of N-hydroxymethyl trifluoroacetamide were dissolved in 350 milliliters (ml) dichloromethane in a round-bottom flask equipped with a magnetic stirrer and reflux condenser. Thirty-three ml (0.45 mole) thionyl chloride were added dropwise with vigorous stirring. The reaction mixture was heated at reflux until the gas evolution ceased. The resulting mixture was then stripped under reduced pressure to yield the desired product.

Workup

  1. customequipped with a magnetic stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture was heated
  4. temperatureat reflux until the gas evolution

Sources & evidence

ORD record
ord-3aa86f7841ab49deb09b39cabe34b0a3
Source dataset
uspto-grants-1986_02
Patent number
US04569802

Reaction notes

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