Thionyl Chloride → HCID 13561107, compound

Participants

Reaction Steps

51.7 grams (g) (0.36 mole) of N-hydroxymethyl trifluoroacetamide were dissolved in 350 milliliters (ml) dichloromethane in a round-bottom flask equipped with a magnetic stirrer and reflux condenser. Thirty-three ml (0.45 mole) thionyl chloride were added dropwise with vigorous stirring. The reaction mixture was heated at reflux until the gas evolution ceased. The resulting mixture was then stripped under reduced pressure to yield the desired product.

Provenance & Evidence