Ethanol → H-Leu-Gly-OEt.HCl

HRID 1589348Notes

Reaction equation

HRID 1589348 reaction equation
[NH2:1][C@H:2]([C:7]([NH:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].O=S(Cl)[Cl:16].[CH2:18](O)[CH3:19]>>[ClH:16].[CH2:18]([O:12][C:11](=[O:13])[CH2:10][NH:9][C:7](=[O:8])[C@H:2]([CH2:3][CH:4]([CH3:5])[CH3:6])[NH2:1])[CH3:19]

Participants

4

Reactant 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 97364Leu-Gly

Product 1

HCID 13334684H-Leu-Gly-OEt.HCl

Procedure

To a solution of leucylglycine (5 g, 27 mmol) in 30 ml ethanol cooled to 0° was added SOCl2 (4.1 g, 35 mmol). The reaction solution was stirred overnight at room temperature. The ethanol was removed in vacuo, yielding a glassy product with a consistent mass spectrum, nmr and a single peak in the HPLC.

Workup

  1. customThe ethanol was removed in vacuo
  2. customyielding a glassy product with a consistent mass spectrum

Sources & evidence

ORD record
ord-c338b0c6f018486aad287e2750bece4c
Source dataset
uspto-grants-1986_02
Patent number
US04569907

Reaction notes

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