Sodium ion → 4-[2-(4-Methoxy-benzyl)-1-oxo-7-phenyl-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

HRID 158940Notes

Reaction equation

HRID 158940 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]1.[CH3:44][C:45]([N:46]([CH3:47])[CH3:48])=[O:49].[F:17][c:18]1[cH:19][c:20]2[cH:21][cH:22][n:23]([CH2:35][c:36]3[cH:37][cH:38][c:39]([O:42][CH3:43])[cH:40][cH:41]3)[c:24](=[O:34])[c:25]2[cH:26][c:27]1-[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[H-:15].[Na+:16]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:18]2[cH:19][c:20]3[cH:21][cH:22][n:23]([CH2:35][c:36]4[cH:37][cH:38][c:39]([O:42][CH3:43])[cH:40][cH:41]4)[c:24](=[O:34])[c:25]3[cH:26][c:27]2-[c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 31374DimethylacetamideHCID 166653HydrideHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 576525476-Fluoro-2-[(4-methoxyphenyl)methyl]-7-phenylisoquinolin-1(2H)-one

Product 1

HCID 576525764-[2-(4-Methoxy-benzyl)-1-oxo-7-phenyl-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-2471a8c919274855a337ce019c8178e4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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