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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1589407Generated: November 2, 2026

Hydrochloric Acid → 2-amino-5-((6-methyl-3-pyridyl)hydroxymethyl)-4(1H)-pyrimidinone

https://huagongshe.com/reaction/1589407

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantIsocytosineHCID 66950—
Reactant6-Methyl-3-pyridinecarboxaldehydeHCID 10192566—
Product2-amino-5-((6-methyl-3-pyridyl)hydroxymethyl)-4(1H)-pyrimidinoneHCID 178425693—

Reaction Steps

Isocytosine is reacted with 2-methyl-5-formyl pyridine in refluxing concentrated hydrochloric acid for 24 hours to give 2-amino-5-((6-methyl-3-pyridyl)hydroxymethyl)-4(1H)-pyrimidinone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04569996
Source datasetuspto-grants-1986_02
ORD IDord-6be31b3a2faa4cda91f888d378f8b9d5
Source noteuspto-grants-1986_02