Hydrochloric Acid → 2-amino-5-((6-methyl-3-pyridyl)hydroxymethyl)-4(1H)-pyrimidinone

HRID 1589407Notes

Reaction equation

HRID 1589407 reaction equation
[CH:1]1[C:6](=[O:7])[NH:5][C:4]([NH2:8])=[N:3][CH:2]=1.[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]=[O:17])=[CH:12][N:11]=1.Cl>>[NH2:8][C:4]1[NH:3][CH:2]=[C:1]([CH:16]([C:13]2[CH:12]=[N:11][C:10]([CH3:9])=[CH:15][CH:14]=2)[OH:17])[C:6](=[O:7])[N:5]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66950IsocytosineHCID 101925666-Methyl-3-pyridinecarboxaldehyde

Product 1

HCID 1784256932-amino-5-((6-methyl-3-pyridyl)hydroxymethyl)-4(1H)-pyrimidinone

Procedure

Isocytosine is reacted with 2-methyl-5-formyl pyridine in refluxing concentrated hydrochloric acid for 24 hours to give 2-amino-5-((6-methyl-3-pyridyl)hydroxymethyl)-4(1H)-pyrimidinone.

Sources & evidence

ORD record
ord-6be31b3a2faa4cda91f888d378f8b9d5
Source dataset
uspto-grants-1986_02
Patent number
US04569996

Reaction notes

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