Potassium Carbonate → HCID 20246579, compound
Reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)=[CH:6][CH:7]=1.[NH2:18][CH2:19][CH:20](O)[CH2:21][CH2:22][CH3:23].C(=O)([O-])[O-].[K+].[K+]>O.C(O)C>[CH2:21]([CH:20]1[N:3]2[N:4]=[C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=3)[CH:6]=[CH:7][C:2]2=[N:18][CH2:19]1)[CH2:22][CH3:23]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 130 °C
Procedure
A mixture of 3.0 g of 3-chloro-6-[3-(trifluoromethyl)phenyl]pyridazine and 5.0 g of 1-amino-2-pentanol is heated at 130° C. for 18 hours, cooled, diluted with water and extracted with dichloromethane. As for Example 3, the obtained product is reacted with thionyl chloride and the ring is closed with potassium carbonate in ethanol to give 2,3-dihydro-3-propyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine which is dehydrogenated with lead tetraacetate to give the product of the Example.
Workup
- temperaturecooled
- extractionextracted with dichloromethane
- customAs for Example 3, the obtained product is reacted with thionyl chloride
Sources & evidence
- ORD record
- ord-c9408d8936854fb78e1d6bed37b95cda
- Source dataset
- uspto-grants-1986_02
- Patent number
- US04569934
Reaction notes
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