反应详情

温度

130 °C

A mixture of 5.0 g of 3-chloro-6-[3-(trifluoromethyl)phenyl]pyridazine and 10 g of 2-amino-1-pentanol is heated at 130° C. for 24 hours, cooled, poured into water and extracted with dichloromethane. As for Example 3, the obtained product is reacted with thionyl chloride and the ring is closed with potassium carbonate in ethanol to give 2,3-dihydro-2-propyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine which is dehydrogenated with lead tetraacetate to obtain the desired product.

1. temperaturecooled
2. extractionextracted with dichloromethane
3. customAs for Example 3, the obtained product is reacted with thionyl chloride