反应详情

To 34 g. of the product obtained in the above (b) step, there were added 23 g. of potassium hydroxide, 10 ml. of water and 70 ml. of propylene glycol, and the mixture was stirred at 130° C. for 7 hours. The reaction mixture was made acidic by addition of hydrochloric acid, and was then extracted with n-hexane. The extract was washed with water and dried, and the solvent was removed by evaporation. The residue was purified by silica gel column chromatography to obtain 30 g. of the desired oily product.

1. additionwere added 23 g
2. extractionwas then extracted with n-hexane
3. washThe extract was washed with water
4. customdried
5. customthe solvent was removed by evaporation
6. customThe residue was purified by silica gel column chromatography
7. customto obtain 30 g