HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isobutyl Ketone → 5-[[2-hydroxy-3-[3-(1-pieridinylmethyl)phenoxy]propyl]amino]-1-methyl-1H-1,2,4-triazole-3-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isobutyl Ketone | HCID 7909 | — |
| Reactant | 1-Amino-3-{3-[(dimethylamino)methyl]phenoxy}propan-2-ol | HCID 13280134 | — |
| Reactant | Methyl N-[2-(acetyloxy)acetyl]-1-methyl-2-(phenylmethylene)hydrazinecarboximidothioate | HCID 53735339 | — |
| Product | 5-[[2-hydroxy-3-[3-(1-pieridinylmethyl)phenoxy]propyl]amino]-1-methyl-1H-1,2,4-triazole-3-methanol | HCID 20245999 | — |
Reaction Steps
Similarly prepared by this procedure from 1-amino-3-[3-(dimethylaminomethyl)phenoxy]-2-propanol (1.5 g) and compound B (2.25 g) except that the methyl isobutyl ketone extract was evaporated to give a solid which was washed with diethyl ether and then recrystallised from methyl acetate was 5-[[3-[3-(dimethylaminomethyl)phenoxy]-2-hydroxy-propyl]amino]-1-methyl-1H-1,2,4-triazole-3-methanol (250 mg) m.p. 104°-109°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04571394 |
| Source dataset | uspto-grants-1986_02 |
| ORD ID | ord-20795e82c31041db8158a8cef02993c5 |
| Source note | uspto-grants-1986_02 |