Potassium Hydroxide → HCID 70455272, compound

HRID 1589543Notes

Reaction equation

HRID 1589543 reaction equation
C([O:4][CH:5]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][N:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[CH:21]=1)[CH2:6][NH:7][C:8]1[N:12]([CH3:13])[N:11]=[C:10]([NH:14][C:15](=[O:17])[CH3:16])[N:9]=1)(=[O:3])C.[OH-].[K+]>C(O)C>[OH2:3].[OH:4][CH:5]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][N:27]2[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]2)[CH:21]=1)[CH2:6][NH:7][C:8]1[N:12]([CH3:13])[N:11]=[C:10]([NH:14][C:15](=[O:17])[CH3:16])[N:9]=1.[OH:4][CH:5]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][N:27]2[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]2)[CH:21]=1)[CH2:6][NH:7][C:8]1[N:12]([CH3:13])[N:11]=[C:10]([NH:14][C:15](=[O:17])[CH3:16])[N:9]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 53808649HCID 53808649, compound

Product 1

HCID 70455272HCID 70455272, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1-[[3-(acetylamino)-1-methyl-1H-1,2,4-triazol-5-yl]amino]-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol acetate (ester) (0.32 g) and 0.9M aqueous potassium hydroxide (1.0 ml) in ethanol (25 ml) was stirred for 0.5 h at 23°. The ethanol was evaporated, and the residue was suspended in sodium carbonate solution. This solution was extracted with methyl acetate. The extract was dried, and evaporated to give a gum, which was chromatographed using system A to give the title compound (0.25 g) as a white foam.

Workup

  1. customThe ethanol was evaporated
  2. extractionThis solution was extracted with methyl acetate
  3. customThe extract was dried
  4. customevaporated
  5. customto give a gum, which
  6. customwas chromatographed

Sources & evidence

ORD record
ord-dba86529254241d7933eecd1c47f5ef0
Source dataset
uspto-grants-1986_02
Patent number
US04571394

Reaction notes

Loading…