Potassium Hydroxide → HCID 70455272, compound

Participants

Reaction Steps

A solution of 1-[[3-(acetylamino)-1-methyl-1H-1,2,4-triazol-5-yl]amino]-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol acetate (ester) (0.32 g) and 0.9M aqueous potassium hydroxide (1.0 ml) in ethanol (25 ml) was stirred for 0.5 h at 23°. The ethanol was evaporated, and the residue was suspended in sodium carbonate solution. This solution was extracted with methyl acetate. The extract was dried, and evaporated to give a gum, which was chromatographed using system A to give the title compound (0.25 g) as a white foam.

Provenance & Evidence