1-Methylpiperazine → 2-Ethyl-6-hydrazinyl-4-(4-methyl-1-piperazinyl)pyrimidine

HRID 1589633Notes

Reaction equation

HRID 1589633 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][NH2:9])[N:5]=[C:4]([CH2:10][CH3:11])[N:3]=1.[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>O>[CH2:10]([C:4]1[N:3]=[C:2]([N:16]2[CH2:17][CH2:18][N:13]([CH3:12])[CH2:14][CH2:15]2)[CH:7]=[C:6]([NH:8][NH2:9])[N:5]=1)[CH3:11]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 133936134-Chloro-2-ethyl-6-hydrazinylpyrimidine

Product 1

HCID 133936142-Ethyl-6-hydrazinyl-4-(4-methyl-1-piperazinyl)pyrimidineYield 70.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 8.3 g (0.05 mole) of 4-chloro-2-ethyl-6-hydrazinylpyrimidine and 11 g (0.10 mole) of 1-methylpiperazine in 250 ml of water was heated at reflux for 16 hours and was then cooled and extracted with chloroform. The extracts were dried over magnesium sulfate and were then evaporated to provide 8.3 g (70%) of 2-ethyl-6-hydrazinyl-4-(4-methyl-1-piperazinyl)pyrimidine.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. temperaturewas then cooled
  4. extractionextracted with chloroform
  5. dry with materialThe extracts were dried over magnesium sulfate
  6. customwere then evaporated

Sources & evidence

ORD record
ord-e37d59af6b7345d9852cc3896cdc8b74
Source dataset
uspto-grants-1986_02
Patent number
US04572910

Reaction notes

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