反应详情

3-Amino-1-(4-chlorophenyl)-2-pyrazoline (prepared in Reference Example 6 of our European patent specification No. 22-578) (1.95 g) in S.V.M. (5 ml) was mixed with excess 4-chlorobenzaldehyde (1.50 g) and the mixture was heated to reflux after the addition of 1 drop of glacial acetic acid. A virtually clear solution formed which rapidly crystallised to form a bright orange product which was collected, washed with S.V.M. and dried in vacuo to produce 2.95 g 3-(4-chlorobenzylideneamino)-1-(4-chlorophenyl)-2-pyrazoline, m.p. 193°-195° (decomp).

1. temperaturethe mixture was heated
2. temperatureto reflux
3. customA virtually clear solution formed which
4. customrapidly crystallised
5. customto form a bright orange product which
6. customwas collected
7. washwashed with S.V.M
8. customand dried in vacuo