Hydrochloric Acid → HCID 9909665, compound

HRID 1589687Notes

Reaction equation

HRID 1589687 reaction equation
C([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[CH3:15])[O:11][C:10]([CH2:17][O:18][C:19]1[CH:32]=[CH:31][C:22]([CH2:23][CH:24]3[S:28][C:27](=N)[NH:26][C:25]3=[O:30])=[CH:21][CH:20]=1)([CH3:16])[CH2:9][CH2:8]2)(=O)C.Cl.C[O:35]CCO>>[OH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[CH3:15])[O:11][C:10]([CH2:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:23][CH:24]3[S:28][C:27](=[O:35])[NH:26][C:25]3=[O:30])=[CH:31][CH:32]=1)([CH3:16])[CH2:9][CH2:8]2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 80192-MethoxyethanolHCID 141548937HCID 141548937, compound

Product 1

HCID 9909665HCID 9909665, compound

Procedure

170 mg of 5-[4-(6-acetoxy-2,7-dimethylchroman-2-ylmethoxy)benzyl]-2-iminothiazolidin-4-one (prepared as described in Example 5) were added to a mixture of 0.2 ml of 2N hydrochloric acid and 2 ml of ethylene glycol monomethyl ether, and the mixture was reacted at 95°-97° C. for 6 hours. It was then processed and purified as described in Example 1(a), except that the crude product, in the form of an oil, was subjected to column chromatography through silica gel, eluted with a 9:1 by volume mixture of benzene and ethyl acetate, to give the title compound.

Workup

  1. customthe mixture was reacted at 95°-97° C. for 6 hours
  2. custompurified
  3. washeluted with a 9:1 by volume mixture of benzene and ethyl acetate

Sources & evidence

ORD record
ord-035de3d66e3b4f60a27430ac0ca9c38a
Source dataset
uspto-grants-1986_02
Patent number
US04572912

Reaction notes

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