Hydrochloric Acid → N-(n-butyl)-2-[4-(5-trifloromethyl-2-pyridyloxy)phenoxy]-propionic acid amide

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Reaction Steps

A mixture containing 17.1 g (0.05 mol) of methyl 2-[4-(5-trifluoromethyl-2-pyridyloxy)-phenoxy]-propionate and 7.3 g (0.1 mol) of n-butylamine is heated at 80°-85° C. for 6 hours while stirring, then cooled and diluted with 50 ml of benzene. The benzene solution is shaken with 5% aqueous hydrochloric acid solution and then washed with water to acid-free. After separation the organic phase is dried over anhydrous sodium sulfate and evaporated to dryness. The crude product can be recrystallized from a mixture of benzene with petroleum ether (b.p. 70° C.) The compounds Nos. 1, 6, 7 and 8 are similarly prepared from the corresponding starting materials.

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