反应详情

A mixture containing 17.1 g (0.05 mol) of methyl 2-[4-(5-trifluoromethyl-2-pyridyloxy)-phenoxy]-propionate and 7.3 g (0.1 mol) of n-butylamine is heated at 80°-85° C. for 6 hours while stirring, then cooled and diluted with 50 ml of benzene. The benzene solution is shaken with 5% aqueous hydrochloric acid solution and then washed with water to acid-free. After separation the organic phase is dried over anhydrous sodium sulfate and evaporated to dryness. The crude product can be recrystallized from a mixture of benzene with petroleum ether (b.p. 70° C.) The compounds Nos. 1, 6, 7 and 8 are similarly prepared from the corresponding starting materials.

1. temperatureis heated at 80°-85° C. for 6 hours
2. temperaturecooled
3. washwashed with water to acid-free
4. customAfter separation the organic phase
5. dry with materialis dried over anhydrous sodium sulfate
6. customevaporated to dryness
7. customThe crude product can be recrystallized from a mixture of benzene with petroleum ether (b.p. 70° C.) The compounds Nos
8. custom1, 6, 7 and 8 are similarly prepared from the corresponding starting materials