反应详情

A mixture containing 12.46 g of 2-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]propionic acid and a catalytic amount of p-toluenesulfonic acid in 70 ml of methanol is boiled under reflux for 4 hours. After evaporating the solution to dryness, the residue is dissolved in ether and washed with sodium hydrogen carbonate solution. The ethereal layer is separated, dried over anhydrous magnesium sulfate and evaporated to dryness to give 11.5 g of product.

1. temperatureunder reflux for 4 hours
2. customAfter evaporating the solution to dryness
3. dissolutionthe residue is dissolved in ether
4. washwashed with sodium hydrogen carbonate solution
5. customThe ethereal layer is separated
6. dry with materialdried over anhydrous magnesium sulfate
7. customevaporated to dryness