反应详情

106 g (0.44 mol) of 4-(trans-4'-propylcyclohexyl) benzyl cyanide, 40 g of water, 145 g (2.2 mol) of KOH and 440 cm3 of methanol were refluxed for 10 hours using a mantle heater. The ethanol was distilled off under reduced pressure. The residue was dissolved in 300 cm3 of water and poured into 300 cm3 of concentrated hydrochloric acid and 300 g of ice. The crystals deposited were filtered out and washed with cold water. The crystals were recrystallized from methanol to yield 112 g (0.43 mol) of 4-(trans-4'-propylcyclohexyl)phenyl acetic acid.

1. distillationThe ethanol was distilled off under reduced pressure
2. dissolutionThe residue was dissolved in 300 cm3 of water
3. additionpoured into 300 cm3 of concentrated hydrochloric acid and 300 g of ice
4. filtrationThe crystals deposited were filtered out
5. washwashed with cold water
6. customThe crystals were recrystallized from methanol