Water → HCID 178447875, compound

Participants

Reaction Steps

106 g (0.44 mol) of 4-(trans-4'-propylcyclohexyl) benzyl cyanide, 40 g of water, 145 g (2.2 mol) of KOH and 440 cm3 of methanol were refluxed for 10 hours using a mantle heater. The ethanol was distilled off under reduced pressure. The residue was dissolved in 300 cm3 of water and poured into 300 cm3 of concentrated hydrochloric acid and 300 g of ice. The crystals deposited were filtered out and washed with cold water. The crystals were recrystallized from methanol to yield 112 g (0.43 mol) of 4-(trans-4'-propylcyclohexyl)phenyl acetic acid.

Provenance & Evidence