Ammonia → 123688-60-8

HRID 1589753Notes

Reaction equation

HRID 1589753 reaction equation
[NH3:1].[ClH:2].[Br:3][C:4]1[C:12]([F:13])=[CH:11][C:7]([C:8](=[NH:10])O)=[CH:6][C:5]=1[F:14]>C(O)C>[ClH:2].[Br:3][C:4]1[C:12]([F:13])=[CH:11][C:7]([C:8]([NH2:1])=[NH:10])=[CH:6][C:5]=1[F:14]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178479548HCID 178479548, compound

Product 1

HCID 19838583123688-60-8

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

450 cm3 of anhydrous ethanol saturated with dried gaseous ammonia was added to 4-bromo-3,5-difluorobenzimidate hydrogen chloride and stirred overnight at room temperature. About one-half of the volume of the solvent was distilled off and the residue was recrystallized to yield 90 g (0.36 mol) of 4-bromo-3,5-difluorobenzamidine hydrogen chloride.

Workup

  1. distillationAbout one-half of the volume of the solvent was distilled off
  2. customthe residue was recrystallized

Sources & evidence

ORD record
ord-f6eec6f26b3e4653a55336994f5e4806
Source dataset
uspto-grants-1993_04
Patent number
US05200110

Reaction notes

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