反应详情

Methyl-D-glucopyranoside (a 2:3 mixture of the α- and β-anomers) (24 g, 0.12 mol, prepared according to Example 6) was esterified with decanoic acid (43 g, 0.25 mol) by the procedure described in Example 1 using 2.4 g of an immobilized lipase (derived from Candida antarctica). After 17 hours the enzyme was removed by filtration (at 80° C.) HPLC analysis of the crude product showed 77% of the title compound, 15% diesters and 8% methyl-D-glucopyranoside. Part of the crude product was purified by chromatography, yielding 39.4 g (59%) of the title compound which was identified by NMR spectroscopy.

1. custom(24 g, 0.12 mol, prepared according to Example 6)
2. customAfter 17 hours the enzyme was removed by filtration (at 80° C.) HPLC analysis of the crude product
3. customPart of the crude product was purified by chromatography