反应详情

A yellow solution of the 5-ethyl-6-methyl-3-nitro-2-(1H)-pyridinone (10 g, 55 mmol) in a mixture of methanol and tetrahydrofuran (100 mL, 1:1 v/v) was reduced catalytically in the presence of 7% palladium on charcoal (0.7 g) under an atmosphere of hydrogen (50 psi) at room temperature over a period of 3.5 hours. The resultant mixture was filtered through a small pad of Celite. The filtrate was concentrated under reduced pressure (15 torr) to provide 5.7 g (68%) of the corresponding aminopyridone.

1. filtrationThe resultant mixture was filtered through a small pad of Celite
2. concentrationThe filtrate was concentrated under reduced pressure (15 torr)