Hydrochloric Acid → 5440-22-2

HRID 1589890Notes

Reaction equation

HRID 1589890 reaction equation
C([NH:4][CH:5]([CH:9]([CH3:11])[CH3:10])[C:6](=[O:8])[CH3:7])(=O)C.[ClH:12]>C(O)C>[ClH:12].[O:8]=[C:6]([CH:5]([NH2:4])[CH:9]([CH3:11])[CH3:10])[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12344670HCID 12344670, compound

Product 1

HCID 149026415440-22-2

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-acetyl-2-keto-3-amino-4-methylpentane (6.33 g, 40.3 mmol) and 6M hydrochloric acid (65 ml) was heated at reflux overnight. The reaction mixture was cooled to room temperature, ethanol (100 ml) was added and the mixture concentrated under reduced pressure The mixture was triturated with ether to give a precipitate which was collected by filtration. Crystallisation from acetone gave 2-keto-3-amino-4-methylpentane hydrochloride. (2.9 9, 63%) as a white crystalline solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationthe mixture concentrated under reduced pressure The mixture
  4. customwas triturated with ether
  5. customto give a precipitate which
  6. filtrationwas collected by filtration
  7. customCrystallisation from acetone

Sources & evidence

ORD record
ord-f0d0d333db4e4aeeb6fb721f72443553
Source dataset
uspto-grants-1993_04
Patent number
US05200412

Reaction notes

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