反应详情

温度

105 °C

A mixture of 3-cyano-2,6-dichloro-4-methylpyridine (270g, 1.44 mole) and concentrated sulfuric acid (530ml) was heated and stirred at 100-110° C. for 3 hours. The resultant mixture was cooled, and poured, with stirring, into 21 of water, to produce a precipitate. The precipitate was neutralized with a sodium hydroxide solution and stirred overnight. The precipitate was then filtered, washed with 31 of water, and dried at 80° C. under vacuum.

1. temperaturewas heated
2. additionpoured
3. customto produce a precipitate
4. stirringstirred overnight
5. filtrationThe precipitate was then filtered
6. washwashed with 31 of water
7. customdried at 80° C. under vacuum