HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 2,6-Dichloro-4-methylnicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Cyano-2,6-dichloro-4-methylpyridine | HCID 70131 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,6-Dichloro-4-methylnicotinamide | HCID 334855 | — |
Reaction Conditions
| Temperature | 105 °C |
|---|
Reaction Steps
A mixture of 3-cyano-2,6-dichloro-4-methylpyridine (270g, 1.44 mole) and concentrated sulfuric acid (530ml) was heated and stirred at 100-110° C. for 3 hours. The resultant mixture was cooled, and poured, with stirring, into 21 of water, to produce a precipitate. The precipitate was neutralized with a sodium hydroxide solution and stirred overnight. The precipitate was then filtered, washed with 31 of water, and dried at 80° C. under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05200522 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-5483b9ed7c13443eafbfcbb3c868d9ae |
| Source note | uspto-grants-1993_04 |