HuagongsheHuagongshe Chemistry Print Report · For research reference only
Perchloric Acid → Triamcinolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Perchloric Acid | HCID 24247 | — |
| Reactant | Triamcinolone | HCID 31307 | — |
| Reactant | Pyruvamide | HCID 79088 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Triamcinolone | HCID 31307 | — |
| Product | acetylpropyl (N-methyl) carboxamide | HCID 23522043 | — |
Reaction Steps
(VI) or triamcinolone is reacted with an acetylcarboxamide in a solution of dichloromethane in the presence of catalytic amount of perchloric acid to produce the corresponding 16α,17-aminocarbonylcyclic acetal pregnane derivatives, e.g., when triamcinolone and acetylpropyl (N-methyl) carboxamide are used the product is (XVIII) 9α-fluoro-11β, 21-dihydroxy-3,20-dioxo-16α,17-(methyl,methylaminocarbonyl-n-propyl)methylenedioxy-1,4-pregnadiene;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05200518 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-d594b8c18c3d44f59eeba5332ff19301 |
| Source note | uspto-grants-1993_04 |