Hydrochloric Acid → 2-Hydroxy-6-vinylbenzoic acid

HRID 1589989Notes

Reaction equation

HRID 1589989 reaction equation
[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([CH:13]=[CH2:14])[C:3]=1[C:4]([O:6]CC)=[O:5].[OH-].[Na+].Cl>CO>[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([CH:13]=[CH2:14])[C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15008897Ethyl 2-hydroxy-6-vinylbenzoate

Product 1

HCID 150088992-Hydroxy-6-vinylbenzoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3 g of ethyl 2-hydroxy-6-vinylbenzoate (see Example 1a), 150 ml of methanol and 45 ml of 10% by weight sodium hydroxide solution was boiled for 8 h. It was then poured into ice-water at pH 1 (hydrochloric acid) and extracted with ethyl acetate, and the solution was dried over sodium sulfate and evaporated under reduced pressure.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialthe solution was dried over sodium sulfate
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-e452d8be7da54b838639450a94d70fbf
Source dataset
uspto-grants-1993_04
Patent number
US05201937

Reaction notes

Loading…