反应详情

To a solution of the propenoate of Step 1 (26.93 g, 0.23 mmol) in THF (20 mL) at 0° C. was added benzyl mercaptan (23.0 mL, 0.23 mol) followed by 1M THF solution of Bu4NF (20 mL). The mixture was stirred at room temperature for 1 hour. The reaction was poured into H2O and extracted with EtOAc, washed with brine, dried and concentrated to yield the title compound. Although the material is essentially pure it can be distilled under vacuum, b.p. 115°-130° C./1 mmHg.

1. extractionextracted with EtOAc
2. washwashed with brine
3. customdried
4. concentrationconcentrated