Glycidyl tosylate → 3-(Pyrazolo[1,5-a]pyrid-4-yloxy)-1,2-epoxypropane

HRID 1590110Notes

Reaction equation

HRID 1590110 reaction equation
[OH:1][C:2]1[C:3]2[N:4]([N:8]=[CH:9][CH:10]=2)[CH:5]=[CH:6][CH:7]=1.S(C1C=CC(C)=CC=1)(O[CH2:15][CH:16]1[O:18][CH2:17]1)(=O)=O>>[N:8]1[N:4]2[CH:5]=[CH:6][CH:7]=[C:2]([O:1][CH2:15][CH:16]3[O:18][CH2:17]3)[C:3]2=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 160868Glycidyl tosylateHCID 15257896Pyrazolo(1,5-a)pyridin-4-ol

Product 1

HCID 152578983-(Pyrazolo[1,5-a]pyrid-4-yloxy)-1,2-epoxypropane

Procedure

4-Hydroxypyrazolo[1,5-a]pyridine (5) as obtained by the above procedure is reacted, in the form of alkali metal salt, with glycidyl tosylate to give 3-(pyrazolo[1,5-a]pyrid-4-yloxy)-1,2-epoxypropane (6). The reaction is preferably carried out in a solvent such as dimethylformamide under an atmosphere of argon gas.

Sources & evidence

ORD record
ord-14df4bc3f46642bdae096f97f4d4fa6e
Source dataset
uspto-grants-1993_04
Patent number
US05202334

Reaction notes

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