反应详情

A solution of O-mesitylenesulfonylhydroxylamine (13.7 g, 44.6 mmole, purity of 70%) in methylene chloride (150 ml) was added dropwise to a solution of 3-benzyloxypyridine (8.25 g, 44.6 mmole) in methylene chloride (150 ml) under ice-cooling, with stirring. The reaction solution was returned to room temperature, stirred for 1 hours and concentrated to one-quarter of the original volume at 20° to 30° C., and ether was added to the concentrate, thereby white crystals were precipitated. This product was used in the next reaction, without being purified.

1. temperaturecooling
2. customwas returned to room temperature
3. stirringstirred for 1 hours
4. concentrationconcentrated to one-quarter of the original volume at 20° to 30° C.
5. additionether was added to the concentrate
6. customwhite crystals were precipitated
7. customThis product was used in the next reaction
8. customwithout being purified