3-Benzyloxypyridine → N-amino-3-benzyloxypyridinium mesitylenesulfonate

Participants

Reaction Steps

A solution of O-mesitylenesulfonylhydroxylamine (13.7 g, 44.6 mmole, purity of 70%) in methylene chloride (150 ml) was added dropwise to a solution of 3-benzyloxypyridine (8.25 g, 44.6 mmole) in methylene chloride (150 ml) under ice-cooling, with stirring. The reaction solution was returned to room temperature, stirred for 1 hours and concentrated to one-quarter of the original volume at 20° to 30° C., and ether was added to the concentrate, thereby white crystals were precipitated. This product was used in the next reaction, without being purified.

Provenance & Evidence