HCID 19100962, compound → 5-Methyl-octahydropyrrolo(3,4-b)pyrrole

HRID 1590144Notes

Reaction equation

HRID 1590144 reaction equation
C([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH2:10][N:11]([CH3:16])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][N:11]1[CH2:10][CH:9]2[CH:13]([CH2:14][CH2:15][NH:8]2)[CH2:12]1

Participants

4

Reactant 1

HCID 19100962HCID 19100962, compound

Product 1

HCID 162288995-Methyl-octahydropyrrolo(3,4-b)pyrrole

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10.3 g (47.6 mmol) of 2-benzyl-7-methyl-2,7-diazabicyclo[3.3.0]octane in 200 ml of ethanol are hydrogenated on 2.5 g of palladium/active carbon (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated, and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-67174bce212c493b97eedae3cd6532e9
Source dataset
uspto-grants-1993_04
Patent number
US05202337

Reaction notes

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