Octahydro-6-methyl-1-(phenylmethyl)pyrrolo[3,4-b]pyrrole → HCID 22924398, compound

HRID 1590146Notes

Reaction equation

HRID 1590146 reaction equation
C([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH:10]([CH3:16])[NH:11][CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][CH:10]1[CH:9]2[CH:13]([CH2:14][CH2:15][NH:8]2)[CH2:12][NH:11]1

Participants

4

Reactant 1

HCID 19100934Octahydro-6-methyl-1-(phenylmethyl)pyrrolo[3,4-b]pyrrole

Product 1

HCID 22924398HCID 22924398, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

7.8 g (36 mmol) of 2-benzyl-8-methyl-2,7-diazabicyclo[3.3.0]octane in 200 ml of ethanol are hydrogenated on 2 g of palladium/active carbon (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated, and the residue is distilled. The distillate crystallises.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-1eb57d90312946f4b11a9381ffb92dcf
Source dataset
uspto-grants-1993_04
Patent number
US05202337

Reaction notes

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