HCID 19100963, compound → HCID 22924370, compound

HRID 1590152Notes

Reaction equation

HRID 1590152 reaction equation
C([N:8]1[CH2:15][CH:14]([CH3:16])[CH:13]2[CH:9]1[CH2:10][NH:11][CH2:12]2)C1C=CC=CC=1>CO.[Pd]>[CH3:16][CH:14]1[CH:13]2[CH:9]([CH2:10][NH:11][CH2:12]2)[NH:8][CH2:15]1

Participants

4

Reactant 1

HCID 19100963HCID 19100963, compound

Product 1

HCID 22924370HCID 22924370, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4.1 g (19 mmol) of 2-benzyl-4-methyl-2,7-diazabicyclo[3.3.0]octane in 80 ml of methanol are hydrogenated on 1 g of palladium/active carbon (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off, the filtrate is concentrated, and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-7cfd6fe38f894d28ae7c202f97feaa49
Source dataset
uspto-grants-1993_04
Patent number
US05202337

Reaction notes

Loading…