反应详情

To a solution of sodium methoxide (1.4 g) in methanol (20 ml}was added a mixture of 3-methylbenzaldehyde (2.4 g) and dimethyl succinate (3.5 g) and the mixture was refluxed for 3 hours. After the reaction mixture was concentrated in vacuo, water was added to the resulting residue and the mixture was washed with diethyl ether. The aqueous layer was acidified with hydrochloric acid and extracted with diethyl ether. The organic layer was washed with brine and dried over MgSO4. The solvent was evaporated under reduced pressure to give 3.8 g of

1. temperaturethe mixture was refluxed for 3 hours
2. concentrationAfter the reaction mixture was concentrated in vacuo, water
3. additionwas added to the resulting residue
4. washthe mixture was washed with diethyl ether
5. extractionextracted with diethyl ether
6. washThe organic layer was washed with brine
7. dry with materialdried over MgSO4
8. customThe solvent was evaporated under reduced pressure
9. customto give 3.8 g of