反应详情

To a solution of benzyl (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate (400 mg) in ethyl acetate (3 ml) was added 10% Pd-C (60 mg) and the mixture was hydrogenolyzed at room temperature and atmospheric pressure for 16 hours. After the catalyst was filtered off, the solvent was evaporated under reduced pressure to give 227 mg of (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid as a colorless viscous oil.

1. customwas hydrogenolyzed at room temperature
2. filtrationAfter the catalyst was filtered off
3. customthe solvent was evaporated under reduced pressure