Triethylamine → HCID 19769932, compound

HRID 1590216Notes

Reaction equation

HRID 1590216 reaction equation
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH:10]([CH2:13][CH2:14][CH2:15][CH3:16])[CH2:11][OH:12])=[CH:4][C:3]=2[O:2]1.C(N(CC)CC)C.[S:24](Cl)([CH3:27])(=[O:26])=[O:25]>ClCCl>[CH3:27][S:24]([O:12][CH2:11][CH:10]([C:5]1[CH:6]=[CH:7][C:8]2[O:9][CH2:1][O:2][C:3]=2[CH:4]=1)[CH2:13][CH2:14][CH2:15][CH3:16])(=[O:26])=[O:25]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 54112566HCID 54112566, compound

Product 1

HCID 19769932HCID 19769932, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 10.2 g (46 mmol) of 2-(3,4-methylenedioxyphenyl) hexyl alcohol, were added 50 ml of dichloromethane and 7.7 ml (55 mmol) of triethylamine, and further added dropwise under cooling with ice 4.3 ml (55 mmol) of mesyl chloride. After stirring for one hour at room temperature, the reaction mixture was washed with saturated aqueous sodium hydrogencarbonate and dried over anhydrous magnesium sulfate. By evaporating off the solvent, 2-(3,4-methylenedioxyphenyl)hexyl methanesulfonate was obtained in an almost quantitative yield.

Workup

  1. additionfurther added dropwise
  2. washthe reaction mixture was washed with saturated aqueous sodium hydrogencarbonate
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customBy evaporating off the solvent

Sources & evidence

ORD record
ord-ffcc16783fe64ff6ad771b2e3e7d1ecb
Source dataset
uspto-grants-1993_04
Patent number
US05202351

Reaction notes

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