Hydroxyamine hydrochloride → HCID 131717848, compound

HRID 1590243Notes

Reaction equation

HRID 1590243 reaction equation
O[C:2]1[C:6](=[O:7])[N:5]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:4][C:3]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14].Cl.[NH2:19][OH:20]>N1C=CC=CC=1>[OH:20][N:19]=[C:2]1[C:6](=[O:7])[N:5]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:4][CH:3]1[C:13]([O:15][CH2:16][CH3:17])=[O:14]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 54691690HCID 54691690, compound

Product 1

HCID 131717848HCID 131717848, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of the title compound of Example D (5.0 g, 20.2 mmol) in 50 ml of pyridine was added hydroxylamine hydrochloride (1.58 g, 24.2 mmol) and the solution was stirred for 16 h at room temperature. Concentration in vacuo gave an oil which was chromatographed on silica gel eluting with EtOH/CH2Cl2 (10/90) to give the title compound (5.18 g, 98%) as a colorless solid. MS calcd for C12H20N2O4 256, found 256.

Workup

  1. concentrationConcentration in vacuo
  2. customgave an oil which
  3. customwas chromatographed on silica gel eluting with EtOH/CH2Cl2 (10/90)

Sources & evidence

ORD record
ord-1ec2c08aea61482a9debf9aa1ce4116d
Source dataset
uspto-grants-1993_04
Patent number
US05202344

Reaction notes

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