反应详情

To ethyl (Z)-2-(hydroxyimino)-2-[2-(triphenylmethyl)aminothiazol-4-yl]acetate(46 g) were added iodo methane(28.4 g), potassium carbonate (27.6 g) and dimethylsulfoxide(500 ml), and the mixture was stirred for 5 hours at room temperature. After ethyl ether(2 l) was added to the reaction mixture, the mixture was washed 5 times with distilled water(500 ml). The separated organic layer was dehydrated with anhydrous magnesium sulfate, filtered, and then concentrated. The residue was chromatographed over silica gel to give the above-indicated compound (35.2 g) as a pale yellow solid.

1. washthe mixture was washed 5 times with distilled water(500 ml)
2. filtrationfiltered
3. concentrationconcentrated
4. customThe residue was chromatographed over silica gel