Hydrochloric Acid → 1,2,3,9-Tetrahydro-3-[(5-methyl-1H-imidazol-4-yl)methyl]-9-methyl-4H-carbazol-4-one hydrochloride monohydrate

HRID 1590463Notes

Reaction equation

HRID 1590463 reaction equation
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][CH:8]1[C:20](=[O:21])[C:19]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([CH3:22])[C:11]=2[CH2:10][CH2:9]1.[ClH:23]>>[OH2:21].[ClH:23].[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][CH:8]1[C:20](=[O:21])[C:19]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([CH3:22])[C:11]=2[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 172316GR 67330

Product 1

HCID 142338961,2,3,9-Tetrahydro-3-[(5-methyl-1H-imidazol-4-yl)methyl]-9-methyl-4H-carbazol-4-one hydrochloride monohydrate

Procedure

A suspension of 1,2,3,9-tetrahydro-3-[(5-methyl-1H-imidazol-4-yl) methyl]-9-methyl-4H-carbazol-4-one (20 g) in IMS (200 ml) was heated to boiling and 2 N hydrochloric acid (50 ml) was added. The resulting solution was allowed to cool to 20°, the resultant suspension was stirred for 1 h and then cooled at 4° for 2 h. The product was filtered off and dried in vacuo at 55° to yield the title compound (20.8 g), m.p. 290° (decomp.).

Workup

  1. additionwas added
  2. temperatureto cool to 20°
  3. temperaturecooled at 4° for 2 h
  4. filtrationThe product was filtered off
  5. customdried in vacuo at 55°

Sources & evidence

ORD record
ord-821a4b57583e43dc9d266d916ebaa246
Source dataset
uspto-grants-1993_04
Patent number
US05202343

Reaction notes

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