N-[2-(chroman-3-yl)ethyl]-N-(2-methoxycarbonylethyl)-amine hydrochloride → 3-{N-[2-(chroman-3-yl)ethyl]amino}propionic acid hydrochloride

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Reaction Steps

The starting material can be prepared, for example, as follows: 3.0 g (0.01 mol) of 3-{N-[2-(chroman-3-yl)ethyl]amino}propionic acid methyl ester hydrochloride are heated at boiling point for 4 hours, with stirring, with 20 ml of 4N hydrochloric acid. The reaction mixture is then concentrated by evaporation under reduced pressure and the residue is stirred with acetone, yielding 3-{N-[2-(chroman-3-yl)ethyl]amino}propionic acid hydrochloride having a melting point of 186°-188°.

Provenance & Evidence