N-[2-(chroman-3-yl)ethyl]-N-(2-methoxycarbonylethyl)-amine hydrochloride → 3-{N-[2-(chroman-3-yl)ethyl]amino}propionic acid hydrochloride

HRID 1590548Notes

Reaction equation

HRID 1590548 reaction equation
[ClH:1].C[O:3][C:4](=[O:20])[CH2:5][CH2:6][NH:7][CH2:8][CH2:9][CH:10]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[O:12][CH2:11]1>Cl>[ClH:1].[O:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:19][CH:10]([CH2:9][CH2:8][NH:7][CH2:6][CH2:5][C:4]([OH:20])=[O:3])[CH2:11]1

Participants

3

Reactant 1

HCID 14838449N-[2-(chroman-3-yl)ethyl]-N-(2-methoxycarbonylethyl)-amine hydrochloride

Product 1

HCID 678559853-{N-[2-(chroman-3-yl)ethyl]amino}propionic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The starting material can be prepared, for example, as follows: 3.0 g (0.01 mol) of 3-{N-[2-(chroman-3-yl)ethyl]amino}propionic acid methyl ester hydrochloride are heated at boiling point for 4 hours, with stirring, with 20 ml of 4N hydrochloric acid. The reaction mixture is then concentrated by evaporation under reduced pressure and the residue is stirred with acetone, yielding 3-{N-[2-(chroman-3-yl)ethyl]amino}propionic acid hydrochloride having a melting point of 186°-188°.

Workup

  1. customfor 4 hours
  2. concentrationThe reaction mixture is then concentrated by evaporation under reduced pressure

Sources & evidence

ORD record
ord-245fe141550747518028bd9be895f02a
Source dataset
uspto-grants-1993_04
Patent number
US05204334

Reaction notes

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