4-Iodobenzoyl chloride → HCID 19767479, compound

HRID 1590599Notes

Reaction equation

HRID 1590599 reaction equation
[CH:1]1([C:5]2([CH2:9][OH:10])[CH2:8][O:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[I:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1>ClCCl.N1C=CC=CC=1>[I:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([O:10][CH2:9][C:5]2([CH:1]3[CH2:4][CH2:3][CH2:2]3)[CH2:8][O:7][CH2:6]2)=[O:17])=[CH:14][CH:13]=1

Participants

5

Reactant 2

HCID 743734-Iodobenzoyl chlorideHCID 19767497HCID 19767497, compound

Product 1

HCID 19767479HCID 19767479, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent2×

Procedure

To a stirred solution of 3-cyclobutyl-3-hydroxymethyloxetane (2.84 g, 20 mmol) in dry dichloromethane (40 ml) and pyridine (3 ml) at 0° C. under nitrogen was added a solution of 4-iodobenzoyl chloride (5.33 g, 20 mmol) in dry dichloromethane (10 ml). The solution was stirred overnight at room temperature, washed with water, dried over anhydrous sodium sulphate and evaporated. (3-Cyclobutyloxetan-3-yl)methyl 4-iodobenzoate was obtained as a white solid (7.42 g, 99%) which was not purified further.

Workup

  1. washwashed with water
  2. dry with materialdried over anhydrous sodium sulphate
  3. customevaporated

Sources & evidence

ORD record
ord-eb716e2ef12443acb087799f88d83bc4
Source dataset
uspto-grants-1993_04
Patent number
US05204333

Reaction notes

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