2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine → 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)benzonitrile

Beteiligte Stoffe

Reaktionsschritte

6-Methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine (6.0 g) was mixed with 3.0 g of CuCN and 50 ml DMF. The mixture was refluxed for 24 hrs. The hot solution was then poured into a (1:4) ethylenediamine-water mixture (200 ml). Using chloroform, the compound was extracted. The chloroform layer was washed with water, dried and evaporated. The residue was crystallized and recrystallized from ethanol; yield; 3.4 g (69%); mp 225°-226° C.

Herkunft & Nachweise