反应详情

6-Methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine (6.0 g) was mixed with 3.0 g of CuCN and 50 ml DMF. The mixture was refluxed for 24 hrs. The hot solution was then poured into a (1:4) ethylenediamine-water mixture (200 ml). Using chloroform, the compound was extracted. The chloroform layer was washed with water, dried and evaporated. The residue was crystallized and recrystallized from ethanol; yield; 3.4 g (69%); mp 225°-226° C.

1. temperatureThe mixture was refluxed for 24 hrs
2. extractionUsing chloroform, the compound was extracted
3. washThe chloroform layer was washed with water
4. customdried
5. customevaporated
6. customThe residue was crystallized
7. customrecrystallized from ethanol