Dimethylamine → HCID 19767710, compound

HRID 1590631Notes

Reaction equation

HRID 1590631 reaction equation
[NH2:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[F:18])[C:6]=2[N:7]=1.[CH3:20][NH:21][CH3:22]>C(O)C>[NH2:1][C:2]1[N:3]=[C:4]([N:21]([CH3:22])[CH3:20])[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[F:18])[C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 218745675-amino-7-chloro-3-(2-fluorobenzyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine

Product 1

HCID 19767710HCID 19767710, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.8 g (10 mmol) of 5-amino-7-chloro-3-(2-fluorobenzyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine are dissolved in 150 ml of ethanol while heating at 40°-50°, and 10 ml of an aqueous solution of dimethylamine (40%) is added to the resulting solution. The reaction mixture is left to stand at room temperature for 2 hours. The precipitated product is then filtered off with suction and washed with water. Recrystallisation from ethanol yields 5-amino-7-(N,N-dimethylamino)-3-(2-fluorobenzyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine having a melting point of 165°-167°.

Workup

  1. temperaturewhile heating at 40°-50°
  2. waitThe reaction mixture is left
  3. filtrationThe precipitated product is then filtered off with suction
  4. washwashed with water
  5. customRecrystallisation from ethanol

Sources & evidence

ORD record
ord-045d84db89504a58b1f8a40f9de7c198
Source dataset
uspto-grants-1993_04
Patent number
US05204353

Reaction notes

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