Dimethylamine → HCID 19767710, compound

Participants

Reaction Steps

2.8 g (10 mmol) of 5-amino-7-chloro-3-(2-fluorobenzyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine are dissolved in 150 ml of ethanol while heating at 40°-50°, and 10 ml of an aqueous solution of dimethylamine (40%) is added to the resulting solution. The reaction mixture is left to stand at room temperature for 2 hours. The precipitated product is then filtered off with suction and washed with water. Recrystallisation from ethanol yields 5-amino-7-(N,N-dimethylamino)-3-(2-fluorobenzyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine having a melting point of 165°-167°.

Provenance & Evidence